CDK-IN-18
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant and selective inhibitor of CDK2, CDK4, and CDK6. CDK-IN-18 inhibits the activity of cyclin-CDK complexes, blocks phosphorylation of the retinoblastoma protein (pRb), arresting the cell cycle transition from G1 to S phase. CDK-IN-18 is promising for research of cancers, such as breast cancer (especially hormone receptor-positive, HER2-negative type), lung cancer, and colorectal cancer[1][2].
2531743-46-9
12352005
CDK
Cell Cycle/DNA Damage
Cancer
CC(C1=C2N(N=C1)C=CC(C3=NC(NC4=CC=C(N5C(C[C@H](CC5)N(C)C)=O)C=N4)=NC=C3)=C2)C
C26H30N8O
470.57
[1]Zhilong Hu, et al. Cdk inhibitors. WO2020224568A1. 2020-11-12.|[2]Xiaotian Zhu, et al. Salt and solid forms of a cdk inhibitor. WO2025103447A1. 2025-05-22.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-201330/
Reference compound1
No Development Reported
CDK2; CDK4; CDK6
Beschrijving
CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant and selective inhibitor of CDK2, CDK4, and CDK6. CDK-IN-18 inhibits the activity of cyclin-CDK
Specificaties
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