CDNF Aanbevolen eiwit

CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.

441549

Q49AH0

NP_001025125.2

Recombinant Proteins

E. coli

Neuroscience

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Room Temp

The lyophilized CDNF recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted CDNF stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing CDNF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Cerebral dopamine neurotrophic factor

Homo sapiens

ARMETL1, ARMETL1, Cerebral dopamine neurotrophic factor, ARMET-like protein 1

Human

82880674

Lyophilized