CDX-1140
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CDX-1140 is a human IgG2 CD40 agonist antibody. CDX-1140 activates dendritic cells (DCs) and B cells and drives NF-kB stimulation in a CD40-expressing reporter cell line. CDX-1140 is independent of FcR binding and synergistic with native CD40L signaling. CDX-1140 has both direct and immune-mediated anti-tumor activity. CDX-1140 can be used for the study of lymphoma cancer and solid tumors[1][2].
12352203
TNF Receptor
Apoptosis
Cancer-programmed cell death
Cancer
[1]Vitale LA, et al. Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy. Cancer Immunol Immunother. 2019 Feb;68 (2) :233-245.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991510/
Inhibitory Antibodies
No Development Reported
Beschrijving
CDX-1140 is a human IgG2 CD40 agonist antibody. CDX-1140 activates dendritic cells (DCs) and B cells and drives NF-kB stimulation in a CD40-expressing reporter
Specificaties
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