C/EBP-alfa (fosfo Thr230) Antilichaam

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.

1050

P49715

NP_004355.2

Human, Mouse, Rat

C/EBP-alpha (phospho Thr230) antibody was raised against a peptide sequence around phosphorylation site of threonine 230 (P-P-T (p) -P-V) derived from Human C/EBP-alpha.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

42 kDa

IgG

The Antibody detects endogenous levels of C/EBP-alpha only when phosphorylated at Thr230.

Western Blot: 1:500~1:1000

CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha

Homo sapiens

Xanthopoulos K.G. Biochem. Biophys. Res. Commun. 215:106-113 (1995)

Schalwijk J. Biol. Chem. Hoppe-Seyler 378:373-379 (1997)

SeattleSNPs variation discovery resource Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases

CCAAT/enhancer-binding protein alpha C/EBP alpha CEBPA

WB

28872794

Liquid