Cefetamet-d3

Cefetamet-d3 (Ro 15-8074-d3; Deacetoxycefotaxime-d3) is the deuterium labeled Cefetamet. Cefetamet (Ro 15-8074) is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet kills and lyses Treponema pallidum. Cefetamet can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis[1][2][3][4][5].

Ro 15-8074-d3; Deacetoxycefotaxime-d3

12352005

Antibiotic; Bacterial; Drug Metabolite; Isotope-Labeled Compounds; Penicillin-binding protein (PBP)

Anti-infection; Metabolic Enzyme/Protease; Others

COVID-19-immunoregulation

Infection

O=C(N[C@@H]([C@@]1(N2C(C(O)=O)=C(CS1)C)[H])C2=O)/C(C3=CSC(N)=N3)=N\OC([2H])([2H])[2H]

C14H12D3N5O5S2

400.45

[1]Bryson HM, et al. Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1993;45 (4) :589-621.|[2]Wang W, et al. Pharmacokinetics and pharmacodynamics of oral and intravenous cefetamet in dog. Eur J Drug Metab Pharmacokinet. 2015 Dec;40 (4) :401-7.|[3]Angehrn P, et al. In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil. Eur J Clin Microbiol Infect Dis. 1989 Jun;8 (6) :536-43. |[4]Wise R, et al. In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites. Antimicrob Agents Chemother. 1986 Jun;29 (6) :1067-72. |[5]Fitzgerald TJ. Effects of cefetamet (Ro 15-8074) on Treponema pallidum and experimental syphilis. Antimicrob Agents Chemother. 1992 Mar;36 (3) :598-602.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W743473/

Isotope-Labeled Compounds

No Development Reported