CENPB Antibody - C-terminal regio : Biotin (ARP51969_P050-Biotin)

Centromere protein B, 80kDa

1059

P07199

NP_001801

Human, Mouse, Rat, Cow, Horse, Pig, Sheep, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human CENPB

CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; RNF2; NR3C1; FBXO25; CENPA; APP; GFI1B; SUMO2; SMN1; PIN1; GSK3B; GADD45A; CSNK2B; CDKN1A; ANXA7; RPS6KA6; TK1; TAC1; TAF1D; PARP1; PARP2; HAND2; CENPB

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 83%; Horse: 86%; Human: 100%; Mouse: 93%; Pig: 86%; Rat: 100%; Sheep: 86%; Yeast: 100%; Zebrafish: 75%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

65kDa

Orthaus, S., (2008) Chembiochem 9 (1), 77-92

Wet Ice

599

CENPB

CENPB

Rabbit

Major centromere autoantigen B

NM_001810

GGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAMVK