
CFS-18
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
FGF-18 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant E.coli derived human FGF-18 is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from c-terminal truncation of the full length protein.
FGF18; ZFGF5; FGF-18
8817
O76093
NP_003853.1
NM_003862
5q34
Human
Mouse, Rat, Human
AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR
< 0.1 ng/µg of protein (< 1EU/µg)
> 95% by SDS-PAGE & HPLC analyses
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml (≥ 2 x 106 units/mg) .
173
Lyophilized
20.1 kDa
E. coli
Beschrijving
FGF-18 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal
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