CFS-20

FGF-20 is secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-20 signals through the FGFR 2c and 3c and is expressed during limb and brain development. Recombinant human FGF-20 is a 23.2 kDa protein containing 209 amino acid residues.

FGF20; FGF-20

26281

Q9NP95

NP_062825.1

NM_019851

8p22

Human

Monkey, Mouse

PLAEVGGFLG GLEGLGQQVG SHFLLPPAGE RPPLLGERRS AAERSARGGP GAAQLAHLHG ILRRRQLYCR TGFHLQILPD GSVQGTRQDH SLFGILEFIS VAVGLVSIRG VDSGLYLGMN DKGELYGSEK LTSECIFREQ FEENWYNTYS SNIYKHGDTG RRYFVALNKD GTPRDGARSK RHQKFTHFLP RPVDPERVPE LYKDLLMYT

Reconstitute in 10mM Tris, pH 7.6, to a concentration of 0.1-1.0 mg/ml

< 0.1 ng/µg of protein (< 1EU/µg)

> 90% by SDS-PAGE & HPLC analyses

The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg.

209

Lyophilized

25mM Tris, pH 7.6 + 1.5M NaCl

25mM Tris, pH 7.6

23.2 kDa

E. coli