CGS 27023A (vrije basis)

CGS 27023A free base is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A free base prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A free base can be used for study of arthritis[1].

161314-70-1

12352005

MMP

Metabolic Enzyme/Protease

Inflammation/Immunology

CC(C)[C@@H](N(S(=O)(C1=CC=C(OC)C=C1)=O)CC2=CC=CN=C2)C(NO)=O

C18H23N3O5S

393.46

[1]MacPherson LJ, et al. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem. 1997;40 (16) :2525-2532.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-18694A/

Reference compound1

No Development Reported

MMP-1; MMP-2; MMP-3; MMP-9