Chaetoglobosine E
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
55945-74-9
Ferroptosis
Apoptosis
Chaetoglobosin E is a ferroptosis inducer exhibiting significant cytotoxicity against the human tumor cell lines MDA-MB231 and A549, with IC50 values of 9.14 μM and 7.47 μM, respectively. It induces ferroptosis by downregulating GPX4 expression in A549 cells, leading to increased intracellular levels of Fe2+ (iron ions) and the lipid peroxidation product malondialdehyde (MDA), resulting in mitochondrial shrinkage and reduced or absent cristae. Chaetoglobosin E is applicable in cancer research.
O=C1[C@]23[C@]([C@H](CC=4C=5C(NC4)=CC=CC5)N1)(C(C)=C(C)[C@@H](O)[C@@]2(/C=C/C[C@H](C)/C=C(\C)/C(=O)[C@@H](O)CCC3=O)[H])[H]
C32H38N2O5
530.654
Ice Packs
-20°C
Beschrijving
Chaetoglobosine E Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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