CHD7 Antilichaam

CHD7 Antibody: CHD proteins belong to a superfamily of proteins of ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. These proteins are thought to play a role in early embryonic development by affecting chromatin structure and gene expression. Mutations in one member of this family, CHD7, result in CHARGE syndrome. It colocalizes with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes.

55636

Q9P2D1

Q9P2D1

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

CHD7 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

CHD7 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CHD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Multiple isoforms of CHD7 are known to exist.

CHD7

Chromodomain helicase DNA binding protein 7

Homo sapiens

Woodage T, Basrai MA, Baxevanis AD, et al. Characterization of the CHD family of proteins. Proc. Natl. Acad. Sci. USA 1997; 94:11472-7.

Cavalli G and Paro R. Chromo-domain proteins: linking chromatin structure to epigenetic regulation. Curr. Opin. Cell Biol. 1998; 10:354-60.

Vissers LE, van Ravenswaaj CM, Admiraal R, et al. Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nat. Genet. 2004; 36:955-7.

Schnetz MP, Handoko L, Akhtar-Zaidi B, et al. CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet. 2010; 6:31001023.

CHD7 Antibody: CRG, HH5, IS3, KAL5, KIAA1416, Chromodomain-helicase-DNA-binding protein 7, ATP-dependent helicase CHD7, CHD-7

ELISA, WB, IHC-P, IF

54112403

Liquid