CHEK1 Antilichaam - middengebied: Biotine (ARP32588 P050-Biotine)

Checkpoint kinase 1

CHK1

1111

O14757

NP_001265

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human CHEK1

CHEK1 is required during normal S phase to avoid aberrantly increased initiation of DNA replication, thereby protecting against DNA breakage. Its expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint.

RELA; CUL4A; UBC; SETMAR; DDB1; TNRC6B; ATR; HECW2; CLSPN; DTL; BTG3; TOPBP1; MAPKAPK2; HSP90AA1; CDC25C; RAD51; PIGM; CUL1; VCP; CDC25A; ATM; APP; MED15; NEK2; TLK1; RB1; BRCA1; FEM1B; XIAP; COPS5; MEPE; LATS2; TP53; Chek1; MEN1; USP7; DNMT1; FANCE; PCNA

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

CHEK1 is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

54kDa

Bennett, L.N., (2008) Biochem. Biophys. Res. Commun. 369 (3), 973-976

Wet Ice

476

CHEK1

CHEK1

Rabbit

Serine/threonine-protein kinase Chk1

NM_001274

SARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF