Chikungunyavirus (CHIKV) E3 & E2 & E1 Proteïne, zijn tag (MALS geverifieerd)

Chikungunya virus (CHIKV) p62 is a structural polyprotein precursor that undergoes furin-mediated cleavage to generate the E3 and E2 glycoproteins. Co-translational association with the fusion protein E1 in the endoplasmic reticulum produces p62–E1 heterodimers that ensure proper folding and spike assembly. Following E3 removal, the mature E2–E1 complex organizes into trimeric spikes on the virion surface, mediating receptor binding and pH-triggered membrane fusion during cell entry. This coordinated processing is essential for CHIKV infectivity and immunogenicity, driving efficient virus assembly.

Chikungunya virus (CHIKV) p62 is a structural polyprotein precursor that undergoes furin-mediated cleavage to generate the E3 and E2 glycoproteins. Co-translational association with the fusion protein E1 in the endoplasmic reticulum produces p62–E1 heterodimers that ensure proper folding and spike assembly. Following E3 removal, the mature E2–E1 complex organizes into trimeric spikes on the virion surface, mediating receptor binding and pH-triggered membrane fusion during cell entry. This coordinated processing is essential for CHIKV infectivity and immunogenicity, driving efficient virus assembly.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 90.6 kDa. The protein migrates as 85-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Pro 266 - Arg 325 & Ser 326 - Gln 666 & Tyr 810 - Pro 1200

E3 & E2 & E1

Unconjugated

C-10xHis

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

90%

Powder

PBS, pH7.4

90.6 kDa

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RT

-20°C

50ug*1

HEK293

Chikungunya virus (CHIKV)

Q1H8W5

Trehalose