Chloorfeniramine-d6

Chlorpheniramine-d6 (Chlorphenamine-d6) is deuterium labeled Chlorpheniramine. Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research[1][2].

1185054-60-7

Chlorphenamine-d6

12352005

Histamine Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

COVID-19-immunoregulation

Inflammation/Immunology

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCC(C1=CC=CC=N1)C2=CC=C(C=C2)Cl

C16H13D6ClN2

280.83

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128.|[3]Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35 (12) :2183-9.|[4]Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471 (3) : p. 223-8.|[5]Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51 (11) : p. 4133-40.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0286S2/

Isotope-Labeled Compounds

No Development Reported