Chloorfenoxamine (hydrochloride)

Chlorphenoxamine hydrochloride, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine hydrochloride inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine hydrochloride shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine hydrochloride is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease[1][2][3][4][5].

562-09-4

12352005

H302

Filovirus; Histamine Receptor; Parasite; SARS-CoV

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Infection; Neurological Disease; Inflammation/Immunology

CC(C1=CC=CC=C1)(C2=CC=C(Cl)C=C2)OCCN(C)C.Cl

C18H23Cl2NO

340.29

P264-P270-P330-P501

[1]ULDALL PR, et al. Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial. Br Med J. 1961 Jun 10;1 (5240) :1649-52.|[2]BAZEX A, et al. Trial treatment of urticaria with chlorphenoxamine. Clinique (Paris) . 1963 Jul-Aug;58:447-50. |[3]Schafer A, et al. Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. Antiviral Res. 2018 Sep;157:47-56. |[4]Ashraf A, et al. Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances. BMC Chem. 2024;18 (1) :133. Published 2024 Jul 19. |[5]Ashraf A, et al. Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation. Sci Rep. 2025;15 (1) :9482. Published 2025 Mar 19.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1607A/

Reference compound1

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