Chlooroxochinoline
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer[1].
23833-97-8
12352005
H302-H315-H319-H335
Cytochrome P450; DNA/RNA Synthesis; ROCK
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad
Cancer
O=C1C=CNC2=C1C=CC(Cl)=C2
C9H6ClNO
179.60
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
[1]Li X, et al. Auto-Induction Effect of Chloroxoquinoline on the Cytochrome P450 Enzymes of Rats Associated with CYP 3A and 1A. PLoS One. 2015 Sep 23;10 (9) :e0138875. |[2]Liu J, et al. [Chloroxoquinoline inhibits invasion in breast cancer via down-regulating Rho/Rho kinase signaling pathway]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 Dec 25;48 (6) :631-637. Chinese.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W110138/
Reference compound2
No Development Reported
Beschrijving
Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell inv
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