ChMAP-28

ChMAP-28 is an antimicrobial peptide. ChMAP-28 can be derived from goat Capra hircus. ChMAP-28 can initiate necrotic death. ChMAP-28 is effective in killing many bacteria, including strains resistant to Polymyxin and Meropenem. ChMAP-28 shows antitumor activity against acute promyelocytic leukemia, epidermoid carcinoma, melanoma, breast adenocarcinoma[1][2].

12352209

Bacterial

Anti-infection

Cancer; Infection

O=C(NC(CCCNC(N)=N)C(NC(CC1=CC=CC=C1)C(NC(CCCCN)C(NC(CCCNC(N)=N)C(NC(CC2=CC=CC=C2)C(NC(CCCNC(N)=N)C(NC(CCCCN)C(NC(CCCCN)C(NC(CC(C)C)C(NC(CCCCN)C(NC(CCCNC(N)=N)C(NC(CC(C)C)C(NC(CC3=CNC4=CC=CC=C34)C(NC(CC5=CNC=N5)C(NC(CCCCN)C(NC(C(C)C)C(NCC(N6C(CCC6)C(NC(CC7=CC=CC=C7)C(NC(C(C)C)C(NCC(N8[C@@H](CCC8)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CC9=CNC=N9)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

C163H255N49O29

3365.08

[1]Emelianova AA, et al. Anticancer Activity of the Goat Antimicrobial Peptide ChMAP-28. Front Pharmacol. 2018 Dec 21;9:1501. |[2]Panteleev PV, et al. Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action. Front Microbiol. 2018 Nov 30;9:2983.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11182/

Peptides

No Development Reported