Cholesterylhemisuccinaat (standaard)

Cholesteryl hemisuccinate (Standard) is the analytical standard of Cholesteryl hemisuccinate. This product is intended for research and analytical applications. Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].

1510-21-0

12352211

Apoptosis; DNA/RNA Synthesis; Necroptosis; Reference Standards; Topoisomerase

Apoptosis; Cell Cycle/DNA Damage; Others

Cancer

99.98

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OC(CCC(O)=O)=O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C

C31H50O4

486.73

[1]Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279 (3) :1470-83.|[2]Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093.

Blue Ice

-20°C, sealed storage, away from light and moisture

http://file.medchemexpress.com/batch_PDF/HY-W010800R/Cholesteryl-hemisuccinate-Standard-SDS-MedChemExpress.pdf

Reference Standards