CHRNB2 Antilichaam - middengebied HRP (ARP34970_T100-HRP)

Cholinergic receptor, nicotinic, beta 2 (neuronal)

EFNL3, nAChRB2

1141

P17787

NP_000739

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig

The immunogen is a synthetic peptide directed towards the middle region of human CHRNB2

Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.

CRELD2; CHRNA4; CHRNA2

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

CHRNB2 is supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 93%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

57kDa

Hales, T.G., (2006) J. Biol. Chem. 281 (12), 8062-8071

Wet Ice

502

CHRNB2

CHRNB2

Rabbit

Neuronal acetylcholine receptor subunit beta-2

NM_000748

CKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWD

Beta-2