CI-1040 (hydrochloride)

CI-1040 (PD 184352) hydrochloride is an orally active, highly specific inhibitor of MEK, with an IC50 of 17 nM for MEK1[1][2][3].

PD 184352 (hydrochloride)

12352101

Apoptosis; MEK

Apoptosis; MAPK/ERK Pathway

Cancer-Kinase/protease

Cancer

O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3.Cl

C17H15Cl2F2IN2O2

515.12

[1]Allen LF, et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) . Semin Oncol. 2003 Oct;30 (5 Suppl 16) :105-16.|[2]Wei CR, et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20 (10) :1961-8. [Content Brief]|[3]Kramer BW, et al. Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040strongly reduces growth and improves lung structure. BMC Cancer. 2004 Jun 1;4:24.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-50295A/

Reference compound1

No Development Reported

MEK1