CI-996
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind [125I]Ang II with an IC50 of 0.8 nM. CI-996 has blood pressure-lowering activity[1].
150438-02-1
12352005
Angiotensin Receptor
GPCR/G Protein
Cardiovascular Disease
O=C(C1=C(N2C(C(C(F)(F)F)=O)=CC=C2)N=C(CCC)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)O
C27H22F3N7O3
549.50
[1]Keiser JA, et al. Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist. J Pharmacol Exp Ther. 1995 Mar;272 (3) :963-9.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19165/
Reference compound1
No Development Reported
AT1 Receptor
Beschrijving
CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind
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