CIAP-antilichaam

CIAP Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.

329

Q13490

NP_001157

Human, Mouse, Rat

3325

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 2) shows similar cIAP expression profile in human, mouse and rat cell lines detected by two independent anti-cIAP antibodies that recognize different epitopes, 3325 against C-terminus domain and competitor antibody against recombinant protein. cIAP proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3325 competitor antibody

Apoptosis, Cancer

CIAP Antibody is affinity chromatography purified via peptide column.

Cat. No. 1331 - Human Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (93%), Chicken: (92%)

CIAP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CIAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human cIAP has 2 isoforms, including isoform 1 (618aa, 70kD) and isoform 2 (569aa, 64kD) . Mouse cIAP has one isoform (612aa, 70kD) and Rat cIAP also has one isoform (589aa, 67kD) . 3325 can detect human, mouse and rat.

BIRC2

Cat. No. 1203 - A549 Cell Lysate

Cat. No. 1220 - SK-N-SH Cell Lysate

Baculoviral IAP repeat-containing 2

Homo sapiens

Schimmer. Cancer Res. 2004; 64:7183-90.

Rothe et al. Cell 1995; 83:1243-52.

Deveraux et al. EMBO J. 1998; 17:2215-23.

Li et al. Nature 2002; 416:345-7.

19906199

22935676

CIAP Antibody: API1, MIHB, HIAP2, RNF48, cIAP1, Hiap-2, c-IAP1, API1, IAP2, Baculoviral IAP repeat-containing protein 2, C-IAP1, IAP-2

ELISA, WB, IHC-P, IF

4502141

Liquid