CIB1 Antilichaam [5A1F5E12 / 5A1H7E12]

CIB1 (also designated calcium and integrin binding 1 or calmyrin), with 191-amino acid protein (about 21 kDa), belongs to the calcium-binding protein family.CIB1 is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining.CIB1 is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alpha (IIb) beta (3) integrin and several serine/threonine kinases and potentially modulates their function.CIB1 regulates platelet aggregation in hemostasis through a specific interaction with the alpha (IIb) cytoplasmic domain of platelet integrin alpha (IIb) beta (3) . CIB1 is also ubiquitously expressed activating and inhibiting protein ligand of the InsP3R.

10519

Q99828

NP_001264693.1

Human

Ni-NTA purified truncated recombinant CIB1 expressed in E. Coli strain BL21 (DE3) .

5A1F5E12 / 5A1H7E12

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

CIB1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

CIB1

Calcium and integrin binding 1 (calmyrin)

Homo sapiens

Holly R. Gentry, Alex U. Singer, Laurie Betts. J. Biol. Chem., Mar 2005; 280: 8407 - 8415.

Carl White, Jun Yang, Mervyn J. Monteiro. J. Biol. Chem., Jul 2006; 281: 20825 – 20833.

CIB, CIBP, KIP1, PRKDCIP, SIP2-28

ELISA, WB, IHC

480540325