CIDE-B Antilichaam

CIDE-B Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes and bone marrow.

27141

Q9UHD4

AF218586

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

CIDE-B Antibody is affinity chromatography purified via peptide column.

Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

1 mg/ml

CIDE-B Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CIDE-B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

CIDE-B antibody has no cross activity to CIDE-A.

CIDEB

Cat. No. 1308 - Human Small Intestine Tissue Lysate

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Cell death-inducing DFFA-like effector b

Homo sapiens

Inohara N, Koseki T, Chen S, et al. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998; 17:2526-33

Inohara N, Koseki T, Chen S, et al. Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD. J. Biol. Chem.1999; 274:270-4.

CIDE-B Antibody: CIDE-B, AI790179, 1110030C18Rik, Cell death activator CIDE-B, Cell death-inducing DFFA-like effector B

ELISA, WB, IHC-P, IF

6746626

Liquid