Cimicifuginezuur D

Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca2+ influx through receptor-operated Ca2+ channels (ROC) in Norepinephrine -induced contraction of rat aortic strips, without affecting voltage-dependent Ca2+ channels (VDC) or K+-induced contractions[1].

219986-51-3

2-Caffeoylpiscidic acid

12352005

Calcium Channel

Membrane Transporter/Ion Channel; Neuronal Signaling

Cardiovascular Disease

OC(C=C1)=CC=C1C[C@@](C(O)=O)(O)[C@@H](C(O)=O)OC(/C=C/C2=CC(O)=C(C=C2)O)=O

C20H18O10

418.35

[1]Noguchi M, et al. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998 Nov;21 (11) :1163-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15735/

Natural Products

No Development Reported