CJ-12255

CJ-12255 is a selective NK1-R antagonist. CJ-12255 has no affinity for the NK-2 or NK-3 receptors. CJ-12255 blocks an substance P (SP) -induced chronic ulcerative colitis (CUC) in rats. CJ-12255 also reduces intraabdominal adhesion formation during abdominal surgery in rats[1][2].

146725-78-2

12352005

Neurokinin Receptor

GPCR/G Protein; Neuronal Signaling

Inflammation/Immunology

O=C([C@H]1C[N@@]2[C@@H](C(C3=CC=CC=C3)C4=CC=CC=C4)[C@@H](NCC5=CC(C(C)C)=CC=C5OC)[C@@]1([H])CC2)O

C32H38N2O3

498.66

[1]Stucchi AF, wt al. A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus. Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285 (6) :G1259-67. |[2]Cohen PA, et al. A neurokinin-1 receptor antagonist that reduces intraabdominal adhesion formation increases peritoneal matrix metalloproteinase activity. Wound Repair Regen. 2007 Nov-Dec;15 (6) :800-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19182/

Reference compound1

Phase 1

NK1R