Claudin 3 (fosfo Tyr219) Antilichaam

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands.

1365

O15551

NP_001297.1

Human

Claudin 3 (phospho Tyr219) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 219 (R-K-D-Y (p) -V) derived from Human Claudin 3.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

28 kDa

IgG

The antibody detects endogenous levels of Claudin 3 only when phosphorylated at tyrosine 219.

Western Blot: 1:500~1:1000

CLDN3

Claudin 3

Homo sapiens

Peacock R.E., Genomics 46:443-449 (1997) .

Katahira J., J. Biol. Chem. 272:26652-26658 (1997) .

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

CLD3, CLDN3, HRVP1, CPE-R 2, CPE-receptor 2

WB

6685273

Liquid