Claudin 6 Antilichaam / CLDN6

Claudin 6 is a protein that in humans is encoded by the CLDN6 gene. It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

Western blot: 1:500-1:1000

Q99808

Mouse

A portion of amino acids 130-159 from the human protein was used as the immunogen for the Claudin 6 antibody.

WB

Antigen affinity purified

Purified

This Claudin 6 antibody is available for research use only.

Aliquot the Claudin 6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the Claudin 6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Western blot testing of mouse heart tissue lysate with Claudin 6 antibody. Predicted molecular weight ~23 kDa.