CLAUDIN4 Antilichaam

CLAUDIN4 Antibody: CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.

1364

O14493

NP_001296

Human

7025

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 1) shows similar CLAUDIN4 expression profile in human cell lines detected by two independent anti-CLAUDIN4 antibodies that recognize different epitopes, 7025 against C-terminus domain and 24-028 against C-terminus domain. CLAUDIN4 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines7025 24-028

Cancer, Cell Cycle

CLAUDIN4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1219 - MCF7 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (94%), Mouse (94%) and Rat (88%) .

CLAUDIN4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CLAUDIN4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of CLAUDIN4 are known to exist; CLAUDIN4 antibody will detect all four isoforms

Human CLAUDIN4 has one isoform (209aa, 22kD) . Mouse CLAUDIN4 has one isoform (210aa, 22kD) and Rat CLAUDIN4 also has one isoform (210aa, 22kD) . 7025 can detect human, mouse and rat.

CLDN4

Cat. No. 1220 - SK-N-SH Cell Lysate

Claudin 4

Homo sapiens

Mitic et al. Protein Sci. 2003; 12:218-27.

Paperna et al. Genomics 1998; 54:453-9.

Morin. Cancer Res. 2005; 65:9603-6.

CLAUDIN4 Antibody: CPER, CPE-R, CPETR, CPETR1, WBSCR8, hCPE-R, CPER, Claudin-4, Clostridium perfringens enterotoxin receptor

ELISA, WB, IF

4502877

Liquid