CLDN11 Antilichaam

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.

5010

O75508

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN11 (NP_005593.2) .

Unconjugated

Primary Antibodies

Immunology, Neuroscience

Affinity purification

NCI-H460

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 23kDa

IgG

CLDN11

DU145

SW480

Mouse kidney

Mouse lung

Rat brain

Claudin 11

Homo sapiens

CLDN11, OSP, OTM

WB, IHC

Liquid