CLEC2A Antilichaam

CLEC2A Antibody: CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8 (+), B lymphocytes and naive CD4 (+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.

387836

Q6UVW9

NP_001124183

Human

Unconjugated

Primary Antibodies

Immunology

CLEC2A Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

CLEC2A Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CLEC2A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

CLEC2A antibody is human specific. Two alternatively spliced transcript variants have been observed.

CLEC2A

Cat. No. 17-004 - K-562 Cell Slide

C-type lectin domain family 2, member A

Homo sapiens

Huarte E, Cubillos-Ruiz JR, Nesbeth YC, et al. PILAR is a novel modulator of human T-cell expansion. Blood 2008; 112:1259-68.

Drickamer K. C-type lectin-like domains. Curr. Opin. Struct. Biol. 1999; 9:585-90

Spreu J, Kienle EC, Schrage B, et al. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. Immunogenetics 2007; 59:903-12.

Spreu J, Kuttruff S, Stejfova V, et al. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc. Natl. Acad. Sci. USA 2010; 107:5100-5.

CLEC2A Antibody: KACL, PILAR, UNQ5792, KACL, UNQ5792/PRO19597, C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin

ELISA, WB, IF

195222725

Liquid