CLEC4M Antilichaam - middengebied: Biotine (ARP42752 P050-Biotine)

C-type lectin domain family 4, member M

CD299, LSIGN, CD209L, L-SIGN, DCSIGNR, HP10347, DC-SIGN2, DC-SIGNR

10332

Q9H2X3

NP_001138378

Human, Horse, Pig

The immunogen is a synthetic peptide directed towards the middle region of human CLEC4M

CLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity.

TLR2; MME; CLEC4M; CD209; ICAM3; ITGAM; AP2M1; HCVgp1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Horse: 79%; Human: 100%; Pig: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

30kDa

Wet Ice

263

CLEC4M

CLEC4M

Rabbit

C-type lectin domain family 4 member M

NM_001144906

CYFMSNSQRNWHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWM