CLIP170 Antilichaam

CLIP170 Antibody: CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.

6249

P30622

NP_002947

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

CLIP170 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

CLIP170 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CLIP170 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

CLIP1

Cat. No. 10-301 - Human Brain Tissue Slide

CAP-GLY domain containing linker protein 1

Homo sapiens

Bilbe G, Delabie J, Bruggen J, et al. Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease. EMBO J.1992; 11:2103-13.

Diamantopoulos GS, Perez F, Goodson HV, et al. Dynamic localization of CLIP-170 to microtubule plus ends is coupled to microtubule assembly. J. Cell Biol.1999; 144:99-112.

Pierre P, Scheel J, Richard JE, et al. CLIP-170 links endocytic vesicles to microtubules. Cell70:887-900.

Suzuki K and Takahashi K. Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells. Biochem. Biophys. Res. Commun.2008; 368:199-204.

CLIP170 Antibody: RSN, CLIP, CYLN1, CLIP170, CLIP-170, RSN, CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1

ELISA, WB, IF

4506751

Liquid