Clozapine N-oxide-d8
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Clozapine N-oxide-d8 is the deuterium labeled Clozapine N-oxide. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
12352005
Dopamine Receptor; Drug Metabolite; Isotope-Labeled Compounds; mAChR
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Neuroscience-Neuromodulation
Neurological Disease
[O-][N+]1(C)C([2H])(C([2H])(N(C([2H])(C1([2H])[2H])[2H])C2=NC3=C(NC4=CC=CC=C24)C=CC(Cl)=C3)[2H])[2H]
C18H11D8ClN4O
350.87
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W748582/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
Clozapine N-oxide-d8 is the deuterium labeled Clozapine N-oxide. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors
Specificaties
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