CLRIG1 Antilichaam [21]

The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL) . Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.

50928

O88713

O88713

Mouse, Human

IL-2-activated NK cells (A-LAK cells) from B6 (H-2b) mice

[2F1]

Unconjugated

Primary Antibodies

Innate Immunity, Immunology

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG

KLRG1

KLRG1 Antibody [2F1] for use in flow cytometry, western blotting, and immunoprecipitation assays.

Klrg1

Killer cell lectin-like receptor subfamily G, member 1

Mus musculus

MAFA, killer cell lectin-like receptor G1, mast cell function-associated-antigen

IHC-Fr, Flow

Liquid