Clusterine-antilichaam

Clusterin Antibody: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide. Clusterin expression is increased in Alzheimer's disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.

1191

P10909

NP_001822

Human, Mouse

Clusterin antibody was raised recombinant human Clusterin isoform 1.

Unconjugated

Primary Antibodies

Neuroscience

Clusterin Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Clusterin Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Clusterin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

CLU

Cat. No. 10-301 - Human Brain Tissue Slide

Clusterin

Homo sapiens

Calero M, Rostagno A, Frangione B, et al. Clusterin and Alzheimer's disease. Subcell. Biochem. 2005; 38:273-98.

Martin-Rehrmann MD, Hoe HS, Capuani EM, et al. Association of apolipoprotein J-positive β -amyloid plaques with dystrophic neurites in Alzheimer's disease brain. Neurotox. Res. 2005; 7:231-42.

Trougakos IP and Gonos ES. Clusterin/Apolipoprotein J in human aging and cancer. Int. J. Biochem. Cell Biol. 2002; 34:1430-48.

Martinon F and Tschopp J. NLRs join TLRs as innate sensors of pathogens. TRENDS Imm. 2005; 26:447-54.

Clusterin Antibody: CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-40, TRPM2, TRPM-2, NA1/NA2, CLI, Clusterin, Aging-associated gene 4 protein, Apo-J

ELISA, WB, IHC-P, IF

42716297

Liquid