CMA1 Antilichaam - C-terminaal gebied: Biotine (ARP59991 P050-Biotine)

Chymase 1, mast cell

CYH, MCT1, chymase

1215

P23946

NP_001827

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the C terminal region of human CMA1

CMA1 is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies.

FYN; IL1B; EDN2; EDN1; KITLG; PFN1; EDN3; MMP1; SERPINA3; AGT

Biotin

Polyclonal Antibody

WB, IHC

Affinity Purified

CMA1 is supported by BioGPS gene expression data to be expressed in COLO205

0.5 mg/ml

Cow: 86%; Dog: 100%; Guinea Pig: 86%; Human: 100%; Mouse: 79%; Rabbit: 79%; Rat: 86%; Sheep: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

27kDa

Wet Ice

247

CMA1

CMA1

Rabbit

Chymase

NM_001836

EVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVA