CNI103

CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases[1].

2366279-86-7

12352209

Phosphatase

Metabolic Enzyme/Protease

Inflammation/Immunology

O=C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)(O)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C(N[C@H](C(NCCOCCOCC(N[C@@H](CCCCNC(CC[C@H](NC([C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=C3C(C=CC=C3)=C2)N4)=O)=O)=O)=O)CCCNC(N)=N)=O)C(N[C@H](CC5=CC=CC=C5)C4=O)=O)=O)C(N)=O)=O)=O)CO)=O)CC(C)C)=O)=O)CCC(N)=O)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)=O)=O)C(C)(C)C)C6=CC=NC(Cl)=C6Cl

C116H180Cl2N36O26

2565.80

[1]Dougherty PG, et al. A Peptidyl Inhibitor that Blocks Calcineurin-NFAT Interaction and Prevents Acute Lung Injury. J Med Chem. 2020 Nov 12;63 (21) :12853-12872.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10889/

Peptides

No Development Reported