Cnidilide

Cnidilide is a natural product of alkylphthalein. Cnidilide can be isolated from the rhizomes of Cnidium officinale. Cnidilide reduces the production of NO and PGE2 by inhibiting the expression of iNOS and COX-2 induced by LPS. Cnidilide can inhibit pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Cnidilide can specifically inhibit the phosphorylation of p38 MAPK and JNK, as well as the activation of downstream kinase MSK-1. Cnidilide blocks the signaling pathway by inhibiting the transcriptional activity of AP-1 and NF-κB. can be used for research on inflammation conditions[1].

3674-03-1

12352005

COX; Interleukin Related; JNK; NF-κB; NO Synthase; p38 MAPK; TNF Receptor

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

COVID-19-immunoregulation

Inflammation/Immunology

CCCC[C@H]1[C@]2([H])[C@](C=CCC2)([H])C(O1)=O

C12H18O2

194.27

[1]Zhang W, et al. Natural phenolic metabolites from endophytic Aspergillus sp. IFB-YXS with antimicrobial activity. Bioorg Med Chem Lett. 2015 Jul 1;25 (13) :2698-701.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16450/

Natural Products

No Development Reported

COX-2; IL-1; IL-6