COASY Antilichaam

Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5) . The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA) . Alternative splicing results in multiple isoforms.

80347

Q13057

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 345-564 of human COASY (NP_079509.5) .

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

Affinity purification

LO2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 62kDa

IgG

COASY

293T

A-549

SKOV3

Mouse heart

Mouse liver

Coenzyme A synthase

Homo sapiens

DPCK, NBIA6, NBP, PCH12, PPAT, UKR1, pOV-2, bifunctional coenzyme A synthase, CoA synthase, bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase, nucleotide binding protein, phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase

WB, IHC

Liquid