COL1A1 Antilichaam

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

1277

P02452

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human COL1A1 (NP_000079.2) .

Unconjugated

Primary Antibodies

Other

Affinity purification

Mouse spleen

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 139kDa

IgG

COL1A1

Mouse kidney

Rat liver

Rat lung

Collagen, type I, alpha 1

Homo sapiens

Alpha-1 type I collagenOI4

WB, IHC, IF

Liquid