Colestolon

Colestolone is a 15-ketosterol compound and an inhibitor of HMG-CoA reductase. Colestolone can inhibit the activity of cholesteryl ester transfer protein (CETP) in vitro (IC50: 660 μM) . Colestolone is a cholesterol-lowering agent, and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia[1].

50673-97-7

12352211

H302-H315-H319-H335

CETP; HMG-CoA Reductase (HMGCR)

Metabolic Enzyme/Protease

Endocrinology; Metabolic Disease

C[C@@]12C(=C3[C@@]([C@]4(C)[C@@](CC3)(C[C@@H](O)CC4)[H])(CC1)[H])C(=O)C[C@@]2([C@@H](CCCC(C)C)C)[H]

C27H44O2

400.64

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Kim HS, et al. Chemical synthesis of 15-ketosterols and their inhibitions of cholesteryl ester transfer protein. Bioorg Med Chem. 1995 Apr;3 (4) :367-74.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W414588/

Reference compound2

No Development Reported