COMT Antilichaam

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

1312

P21964

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT (NP_009294.1) .

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

Affinity purification

MCF-7

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 25kDa, 30kDa

IgG

COMT

HT-29

THP-1

A-431

HepG2

Mouse liver

Catechol-O-methyltransferase

Homo sapiens

COMT, catechol-O-methyltransferase, HEL-S-98n

WB, IP

Liquid