Concanamycine F

Concanamycin F has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research[1].

144539-92-4

12352005

Fungal

Anti-infection

Infection

O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC

C39H64O10

692.92

[1]I Paterson I, et al. Total Synthesis of (+) -Concanamycin F We thank the EPSRC (GR/K54052), Knoll Pharmaceuticals (CASE Studentship to V.A.D.), the Cambridge Commonwealth Trust (M.D.M.), and Merck for support, and Dr R. Norrie (Knoll Pharmaceuticals) for helpful discussions. We also thank Prof. A. Zeeck (Göttingen) for kindly providing copies of (1) H NMR spectra of concanamycin F (concanolide A) . Angew Chem Int Ed Engl. 2000 Apr;39 (7) :1308-1312.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N14426/

Natural Products

No Development Reported