Coprostanon

Coprostanone (5β-cholestan-3-one) is an oxysterol and active metabolite of Cholesterol. Coprostanone induces apoptosis in primary dog gallbladder epithelial cells. Coprostanone is promising for research of colon cancers or adenomatous polyps[1][2].

601-53-6

5β-Cholestan-3-one

12352211

H302, H315, H319, H335

Apoptosis; Drug Metabolite

Apoptosis; Metabolic Enzyme/Protease

Cancer-programmed cell death

Cancer

99.92

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](CC(CC4)=O)([H])CC3)C

C27H46O

386.65

H302, H315, H319, H335

[1]Seo DW, et al. Oxysterols from human bile induce apoptosis of canine gallbladder epithelial cells in monolayer culture. Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287 (6) :G1247-56.|[2]Reddy BS, et al. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer. 1977 Jun;39 (6) :2533-9.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W588187/Coprostanone-SDS-MedChemExpress.pdf

Natural Products

No Development Reported