COPS5 Antilichaam - N-terminal regio : HRP (ARP32834_P050-HRP)

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)

CSN5, JAB1, SGN5, MOV-34

10987

Q92905

NP_006828

Human

The immunogen is a synthetic peptide directed towards the N terminal region of human COPS5

The protein encoded by COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

COPS6; UBC; CUL1; NEDD8; PTGS2; GPS1; LRP1; RANBP9; APP; SIAH1; BACE1; CTNNB1; COPS5; STAT3; CREB3; COPS4; SART3; COPS3; EPB41L1; CAST; KIF5B; PDLIM7; SMAD4; FBXO6; COPS2; TYK2; CDK2; CENPW; CENPT; FBXW4; MYEOV2; COPS8; CHUK; IKBKB; DTL; CD93; DDO; SMAD2

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

38kDa

Oono, K., et al., (2004) Neurochem. Int. 45 (5), 765-772

Wet Ice

334

COPS5

COPS5

Rabbit

COP9 signalosome complex subunit 5

NM_006837

NMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVM

5