Cortactine (fosfo Tyr466) Antilichaam

Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

2017

Q14247

NP_005222.2

Human, Mouse

Cortactin (Phospho-Tyr466) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 466 (P-V-Y (p) -E-T) derived from Human CORTACTIN.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

85 kDa

This antibody detects endogenous level of Cortactin only when phosphorylated at tyrosine 466.

Western Blot: 1:500~1:1000

CTTN

Cortactin

Homo sapiens

Luo C, et al. (2006) J Biol Chem ; 281 (40) : 30081-30093Head JA, et al. (2003) Mol Biol Cell ;14 (8) : 3216-3229Li Y, et al. (2000) J Biol Chem ; 275 (47) : 37187-37193Kinley AW, et al. (2003) Curr Biol ; 13 (5) : 384-393

EMS1, PKB, RAC, Amplaxin, CTTN, EMS1, SRC8

WB

20357552

Liquid