CotH3-peptide

CotH3 peptide is a functional peptide unique to Mucorales that binds to the host GRP78 receptor and allows them to invade endothelial cells. CotH3 peptide–targeted monoclonal antibodies protect immunosuppressed mice from mucormycosis caused by R. delemar and other Mucorales. CotH3 peptide also synergizes with antifungal drugs to protect mice with diabetic ketoacidosis (DKA) from R. delemar infection[1].

12352209

Fungal

Anti-infection

Infection

O=C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N2[C@@H](CCC2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N

C69H105N23O30S

1768.77

[1]Gebremariam T, et al. Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis. Sci Adv. 2019 Jun 12;5 (6) :eaaw1327.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11031/

Peptides

No Development Reported