Cotylenol

Cotylenol is a fungal metabolite with oxygen functions. Cotylenol can be isolated from the culture filtrate of fungal strain, 501-7 w. Cotylenol has optically activity and leaf growth activity. Cotylenol induces the lysozyme activity at concentrations above 50 μg/mL. Cotylenol is a diterpene containing one methoxyl group and three hydroxyl groups, and can be used for synthesis of Cotylenin A as an aglycone part[1][2][3].

41059-90-9

(-) -Cotylenol

12352211

Endogenous Metabolite

Metabolic Enzyme/Protease

Metabolism-protein/nucleotide metabolism

Others

C[C@@]12C([C@H]([C@@H]([C@@H]([C@@]3([H])/C([C@](O)(CC3)COC)=C\2)C)O)O)=C(CC1)C(C)C

C21H34O4

350.49

[1]Sassa T, et al. Production and characterization of a new fungal metabolite, cotylenol[J]. Agricultural and Biological Chemistry, 1972, 36 (13) : 2281-2285. |[2]Kato N, et al. Total synthesis of optically active cotylenol, a fungal metabolite having a leaf growth activity. Intramolecular ene reaction for an eight-membered ring formation [J]. Tetrahedron, 1996, 52 (11) :3921-3932. |[3]Asahi K, et al. Cotylenin A, a plant-growth regulator, induces the differentiation in murine and human myeloid leukemia cells. Biochem Biophys Res Commun. 1997 Sep 29; 238 (3) :758-63.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15596/

Natural Products

No Development Reported