COX11 Antilichaam

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu (B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.

1353

Q9Y6N1

Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human COX11 (NP_004366.1) .

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

Affinity purification

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

IgG

WB: 1:500 - 1:2000

COX11

Cytochrome c oxidase copper chaperone COX11

Homo sapiens

COX11P, cytochrome c oxidase assembly protein COX11, mitochondrial, COX11 homolog, cytochrome c oxidase assembly protein, COX11, cytochrome c oxidase copper chaperone, cytochrome c oxidase subunit 11

WB

Liquid